NAD or Niacin Therapy?

They are the same thing. One has a clinical name the other a vitamin store name. The same horse with a different name.

Pellagra be damned…8)

Type of vitamin B3 safely boosts levels of important cell metabolite

First clinical trial for nicotinamide riboside(VITAMIN B-3 Metabolite) shows promise<—NO/LOW FLUSH NIACIN

Self-study precedes clinical trial

~Source – University of Iowa

Prior to the formal clinical trial, Charles Brenner conducted a pilot human study—on himself. In 2004, he had discovered that NR is a natural product found in milk and that there is a pathway to convert NR to NAD+ in people. More than a decade of research on NR metabolic pathways and health effects in mice and rats had convinced him that NR supplementation had real promise to improve human health and wellness. After consulting with the UI’s institutional review board, he conducted an experiment in which he took 1 g of NR once a day for seven days, and his team analyzed blood and urine samples from him using mass spectrometry. The experiment showed that Brenner’s blood NAD+ increased by about 2.7 times. In addition, though he reported immediate sensitivity to flushing with the related compound niacin, he did not experience any side effects taking NR.


History of NAD(niacin therapy)-nicotinamide riboside.

  • Has been used since the late 1960s in intravenous form to significantly lessen withdrawal from a variety of drugs and alcohol.
  • Mechanism not clear. <–Anti-microbial. Specifically, Antihelmintic. That is anti-worm. Reversing the effects of pellagra and retraining the gut to correct any SIBO.
  • Limitation is that recovery tends not to be complete with IV NAD alone.
  • With addition of [specified amino acids complex], recovery is found to be significantly more profound, complete and lasting.

What Is NAD Therapy?

NAD, or nicotinamide adenine dinucleotide, is a naturally occurring co-enzyme of [NIACIN], vitamin B-3, that helps cells in our bodies produce energy. It does so by converting the energy we get from food into cellular energy. Administering lab-produced NAD will boost the levels of the chemical in someone’s body, but they will need to be administered more to sustain that level. NAD therapy can assist with brain function, DNA repair, and repair signals between molecules for cellular communication. Lastly, it aids in DNA repair. Only with a combination of NAD and regular therapy and support can someone stay on the path of recovery.

As a person abuses drugs and alcohol, their natural amount of NAD is depleted. This makes it more difficult for them to convert the energy that is broken down from food. It is even speculated that people who naturally produce less NAD are more likely to develop an addiction and potentially a co-occurring disorder. Other reasons the body’s natural reserve of NAD would be depleted are:

  • Post-traumatic stress
  • Anxiety
  • Depression
  • Chronic traumatic encephalopathy (CTE)
  • Alzheimer’s
  • Parkinson’s
  • Neurodegenerative diseases
  • Aging

All of these co-occurring disorders can drain one’s energy, and there are many ways to boost NAD in the body by exercising; eating vitamin-rich foods; fasting; eating protein; eating raw foods. Many of these practices are introduced to people in treatment for substance abuse disorders. For instance, yoga and fitness centers are available to encourage healthy lifestyle practices, boost endorphins and will produce lost NAD. Dietary plans can include vitamin-rich foods to boost dopamine and can produce NAD in the brain. Most patients need roughly 6 to 10 days of infusion to feel effects. Often times, individuals enjoy the pleasant feelings, they are less inclined to abuse substances.


Nicotinamide riboside is uniquely and orally bioavailable in mice and humans.

~Source – Nature.com

The first controlled clinical trial of a newly discovered form of vitamin B3, nicotinamide riboside (NR), has shown that the compound is safe for humans. The study also shows NR increases levels of a cell metabolite that is critical for cellular energy production and protection against stress and DNA damage. Studies in mice have shown that boosting the levels of this cell metabolite—nicotinamide adenine dinucleotide, known as NAD+—can produce multiple health benefits, including resistance to weight gain, improved control of blood sugar and cholesterol, reduced nerve damage, and longer lifespan. Levels of NAD+ diminish with age, and other studies have suggested that loss of this metabolite may play a role in age-related health decline.

Nicotinamide riboside is uniquely and orally bioavailable in mice and humans.

~Source – Nature.com

We report that human blood NAD+ can rise as much as 2.7-fold with a single oral dose of NR in a pilot study of one individual, and that oral NR elevates mouse hepatic NAD+ with distinct and superior pharmacokinetics to those of nicotinic acid and nicotinamide.

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